The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.

Previous work from the team had identified a lead compound that could cross the blood brain barrier and target the DNA damage repair protein ataxia telangiectasia mutated (ATM). 3 The protein ...

Scientists have long understood that when both DNA strands are broken, the ATM enzyme triggers the activation of the protein NF-κB within the cell, leading to the production of inflammatory signals.