52 In recent clinical studies, MSLN-targeted therapies have shown promise in treating solid tumors but have raised safety concerns, particularly with respect to lung toxicity. In a phase I/II trial ...

A lung biopsy involves the removal of tissue or growths from the lungs. A doctor will use special devices, such as a fine needle, to remove the sample. A lung biopsy can help diagnose lung ...

The Organoid and Stem Cell Facility (OSCF) at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) provides user lab space, teaching and services in the field of stem cell biology ...

In summary, we demonstrate the development of a novel alveolar organoid model and use it to identify effectors of SFTPC maturation necessary for AT2 health. Disorders of surfactant protein biology ...

Disorders of surfactant protein biology cause dysfunction of alveolar type 2 cells and can lead to interstitial lung disease. This study describes the development of genetically manipulable, mature ...

1Department of Medicine, Columbia Center for Human Development, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York. 2Herbert Irving Comprehensive ...

This marks a significant milestone as SIGX1094 is the first pipeline drug discovered using AI and organoid disease model to enter clinical trials, and the first targeted therapy candidate to ...

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that affects an estimated 2.4 to 3.1 million people in the US alone. Despite decades of research, ...

This marks a significant milestone as SIGX1094 is the first pipeline drug discovered using AI and organoid disease model to enter clinical trials, and the first targeted therapy candidate to address ...