Isovaleric Acidemia is treated with L-leucine restriction and supplemental glycine. Added glycine augments conversion of isovaleric acid (IVA) to isovalerylglycine (IVG) through glycine-N-acylase.

A 72-year-old woman with type 2 diabetes had somnolence after a urologic procedure for bladder cancer. She had respiratory acidosis and anion-gap metabolic acidosis. A diagnosis was made. This ...

The case description for a Case Records of the Massachusetts General Hospital appears below. A 72-year-old woman with type 2 diabetes had somnolence after a urologic procedure for bladder cancer.