Its dual interaction with actin filaments and microtubules highlights its essential role in cytoskeletal organization, such as cell division, apoptosis, and possibly tumorigenesis. However, the ...

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged organelles, and unwanted molecules using powerful digestive enzymes.

These rare neurodegenerative diseases are characterized by the dysfunction of lysosomes, cellular organelles that break down various substances ready for disposal, including proteins, nucleic ...

By Heran Mamo Tommy Richman and Sexyy Red are “Actin Up” together on the new remix that dropped on Friday (April 18). “Bend it over, shake that a–, show that print/ Clean a– bi—, smell ...

The oncogene LAPTM4B (encoding lysosome-associated protein transmembrane-4β), first cloned in hepatocellular carcinoma cells, is located on chromosome 8q22.1 and encodes two isoforms, LAPTM4B-35 and ...

In pink, wild type cells expressing gamma actin. In black, knock-out cells that do not express gamma actin. The yellowish lines reveal the tortuous nature of the ...

The lab also studies mechanisms that regulate autophagy protein and lysosome function in endocytic trafficking and nutrient homeostasis. Cell biologist Michael Overholtzer explores genes that make ...

Notably, highly metastatic triple negative breast cancer cells, that are better adapted at balancing elevated proliferation with invasive capacity also exhibit a dependency on lysosomes and ...

This study reports that activation of TFEB promotes lysosomal exocytosis and clearance of cholesterol from lysosomes, the strength of evidence for which is convincing with appropriate and validated ...