Nature1mon
Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery
Despite major interest in this pathway for cancer drug discovery, no drugs have yet been approved that act specifically against PI3K or its downstream regulator, AKT. However, several drugs that ...
EurekAlert!1d
PP2A regulates CD8+ T cell effector functions through AKT signaling pathway: implications for immunotherapy
A groundbreaking study published in Research (2025, DOI: 10.34133/research.0545) has elucidated the molecular mechanisms by which protein phosphatase 2A (PP2A) regulates CD8+ T cell-mediated immune ...
pharmaphorum1y
AZ first to AKT finish line, but FDA clears narrow label
The company’s head of oncology, Dave Fredrickson, said the approval of Truqap “reinforces the important role of the PI3K/AKT pathway in HR-positive breast cancer and the critical need to test ...
Hosted on MSN12mon
Japan approves AstraZeneca’s Truqap with Faslodex for breast cancer
Progression-free survival in the overall trial population and subjects with PI3K/AKT pathway alterations were the trial's dual primary endpoints. Results from the trial showed that Truqap plus ...