Array Bridge is testing promising drug candidates that can effectively bind and even degrade target proteins, but not via their active sites.

The PI3K/AKT signaling pathway plays a crucial role in the development, survival, and metabolic regulation of the central nervous system, particularly in neuronal growth, differentiation, and ...

The authors discuss several major pathways involved in breast cancer, including PI3K/Akt/mTOR, RAS/RAF/MEK/ERK, HER2, Wnt/β-catenin, Notch, NF-κB, and the DNA damage response (DDR). These ...

Transcriptomic sequencing in mice gingival tissues demonstrated that treatment with c-di-AMP led to a significant upregulation of the PI3K/Akt signaling pathway and its key components, including Akt3.

The authors discuss several major pathways involved in breast cancer, including PI3K/Akt/mTOR, RAS/RAF/MEK/ERK, HER2, Wnt/β-catenin, Notch, NF-κB, and the DNA damage response (DDR). These ...

A new study published in Molecular Medicine Reports finds that nanoparticles made from Cannabis sativa stems could have ...

and a single-hit multitarget model was used to calculate the radiobiological parameters. Cell apoptosis and cell cycle were analyzed by flow cytometry, and the levels of genes and proteins of the ...

此外，涉及 PI3K/Akt/Erk/PTEN/mTOR 的信号通路在缺血性中风后神经元的增殖和维持方面发挥着关键作用。缺血性中风发生后，神经元会面临一系列的生存挑战，如缺氧、能量代谢障碍等。而 PI3K/Akt/Erk/PTEN/mTOR 信号通路可以通过调节神经元内的多种生物学过程 ...

This inhibition disrupts downstream pathways such as MAPK/ERK and PI3K/AKT, preventing cancer cell proliferation and inducing apoptosis. The invention also includes delivery mechanisms to enhance the ...