Further investigation in HG/F-induced H9C2 cells indicated that A-MG inhibits the uptake of fatty acids (FAs) by regulating the AKT/FOXO1/CD36 signaling pathway, reduces excessive β-oxidation of FAs ...

研究证实抑制CHI3L1可通过PI3K-AKT-FoxO1通路减轻肠上皮细胞过度自噬，降低炎症反应和组织损伤。临床数据表明血清CHI3L1水平与疾病严重程度呈正相关，联合传统标志物可显著提高诊断效能(AUC=0.876)，为NEC防治提供了新靶点。 新生儿坏死性小肠结肠炎(NEC)是早产儿最 ...

In atheroprone Apoe −/− mice, ImP increased atherosclerotic lesion size. Mechanistically, ImP attenuated insulin receptor signaling by suppressing the PI3K (phosphoinositide 3-kinase)/AKT pathway ...

Therefore, investigating the upstream molecular mechanisms that activate VEGFA in cancer cells offers new targets for inhibiting TNBC angiogenesis via disruption of this signaling pathway. In this ...

In this study, we discovered that STAMBPL1 facilitates the transcriptional regulation of GRHL3 by interacting with FOXO1, consequently enhancing HIF1A transcription through GRHL3 to activate the HIF1α ...

Moreover, the expression levels of 606 genes appeared to be significantly modulated by miltirone via RNA-seq analyses, and PI3K/AKT signaling pathway was found to refer to miltirone activity.

Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.

Zhejiang Provincial Key Lab for Chemical and Biological Processing Technology of Farm Product, School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou ...