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10 天
γδ IELs 失调或为克罗恩病 “元凶”:小鼠模型研究新发现
徐等人利用自发回肠炎症的小鼠模型发现,在慢性炎症发作前,具有免疫调节作用的回肠 γδ 上皮内淋巴细胞(intraepithelial lymphocytes,IELs)减少。回肠 γδ IELs 的缺失与肠道上皮免疫监视受损以及不太成熟的外周 γδ IELs 的浸润同时发生。这些发现共同表明 ...
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