Mammalian AMP-activated protein kinase (AMPK) was discovered as a protein kinase that switches off lipid synthesis. The yeast orthologue, the SNF1 complex, was discovered in screens for mutations ...

此外，研究团队还发现，哺乳动物在热量限制期间会积累LCA，并激活一种关键代谢分子——AMPK(AMP激活蛋白激酶)。 AMPK是一种能量感应酶，通常在 ...

Diabetes affects millions worldwide, often triggering complications such as insulin resistance and fatty liver disease. To ...

This milestone, achieved in collaboration with Eli Lilly and Company (Lilly), targets a specific isoform of AMP-activated protein kinase (AMPK) for the treatment of cardiometabolic diseases.