RESULTS Immunohistochemical staining disclosed evidence for p53-IR in all specimens in 26.1 (11.5)% of vascular smooth muscle cells (VSMCs) (controls 0.8 (1.3)%; p < 0.001). Bax-IR was present in all ...

Background In hereditary myopathy with early respiratory failure (HMERF), cytoplasmic bodies (CBs) are often localised in subsarcolemmal regions, with necklace-like alignment (necklace CBs), in muscle ...

The stain most used is Giemsa (1 c.c. of stain to 15 c.c. of distilled water). Films are stained by immersion for 20 min. in the diluted stain without previous dehæmoglobinization. While this ...

SANTA ANA, Calif. (KABC) -- All six victims of a crash that claimed the lives of several teenagers in Santa Ana have been identified. The high-speed collision happened Saturday night at the ...

TDP-43 cytoplasmic inclusions and Lewy bodies. Global AD pathology (ie, neuritic plaques, diffuse plaques and neurofibrillary tangles) was visualised in five cortical regions using a modified ...

Normalized protein expression Membrane/cytoplasmic expression ratios Comparative analysis with standard-of-care IHC biomarkers Now available through Akoya’s Advanced Biopharma Services (ABS), the ADC ...

14 Centre for Liver and Gastroenterology research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK 15 NIHR Biomedical Research Centre, University of Birmingham and ...

Department of Applied Chemistry, Osaka Metropolitan University, 1-2 Gakuen, Naka, Sakai, Osaka 599-8570, Japan ...

Neurodegenerative disorders such as Parkinson’s (PD) and Huntington’s disease (HD) are characterized by a selective detrimental impact on neurons in a specific brain area. Currently, these diseases ...

However, these structurally unstable isoforms promote vigorous protein aggregation involving FLp53, disrupting its structure and sequestering it in the cytoplasmic and nuclear aggregates, thereby ...