In the absence of PAMPs, damage-associated molecular patterns (DAMPs) produced by dying cells can stimulate an immune response that can elicit the specific recognition of antigens expressed by ...

An army of defensive cells protects the body against invasion by foreign substances: the antigens. The specialized functions of these various "inflammatory" cells are now being clarified ...

A stable interaction between antigen-presenting cells (APC) and T cells is dependent not only on the absolute affinity between the T-cell receptor (TCR) and its ligand but also on the relative ...

Compromised antigen presentation ranks among the top mechanisms that render cancers non-immunogenic (non-responsive to immune ...

The paper is titled "Neoself-antigens are the primary target for autoreactive T cells in human lupus." Autoimmune diseases develop when the body's immune system mistakenly attacks its own tissues ...

Beyond the Point: Learning From Outcomes After Inpatient Immune Checkpoint Inhibitor Therapy Chimeric antigen receptor T-cell (CAR-T) therapies are standard of care for the treatment of several ...

Typically, dendritic cells present tiny fragments of biological material (known as antigens) for notice by other immune cells called T cells. This programs the T cell to launch an immune attack the ...

PSMA is a dimeric type II integral membrane glycoprotein, highly expressed on prostate cancer cells. It has been shown to be a predictor for prostate cancer ... Targeting the internal epitope of ...

To date, the Food and Drug Administration (FDA) has approved seven chimeric antigen receptor-T (CAR-T) cell therapies and seven bispecific T-cell engagers (BiTEs) across a variety of hematologic ...

Join us for an insightful webinar on the latest advancements in cell and gene therapy, focusing on the innovative Cas9-CLIPT technology. Cas9-CLIPT (Cleaved, Linearized with Protein Template ...