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Natural "off switch" could slow or even reverse the growth of aggressive tumors.

BEIJING, China I March 24, 2025 I SineuGene Therapeutics Co., Ltd. ("SineuGene"), a clinical-stage biotech company pioneering innovative therapies for ...

Cancer disrupts RNA splicing by suppressing poison exons, leading to uncontrolled tumor growth. Researchers at JAX and UConn Health found that targeting TRA2β RNA with antisense oligonucleotides (ASOs ...

GSK has revealed updated results from its phase 2b trial of its antisense drug for hepatitis ... hepatitis B surface antigen (HBsAg) and HBV DNA loss to below the limits of detection in 9% to ...

PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

GSK’s antisense-based drug for chronic hepatitis B (CHB), bepirovirsen, will get a rapid six-month review from the FDA when it is filed for approval, said the drugmaker this morning. The fast ...

In atherosclerosis, the vascular smooth muscle cell (VSMC) contributes to vessel wall inflammation and lipoprotein retention, as well as to the formation of the fibrous cap that provides stability ...

Since 2016, the FDA has approved three disease-modifying treatments for spinal muscular atrophy, with several ...

During the past 20 years, the advent of neoadjuvant, primary, and adjuvant concurrent chemoradiotherapy has improved cancer care dramatically. Significant contributions have been made by ...

Similar in design to glucose monitoring devices, ... Tumor DNA in the Blood Can Predict Lung Cancer Outcome Jan. 13, 2025 — Scientists have found that a test to detect circulating tumor DNA can ...

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...