Purpose The pharmacology, pharmacokinetics, efficacy, and safety of apixaban are reviewed. Summary Apixaban is an oral, direct, selective factor Xa inhibitor with a rapid onset of action.

Participants were randomly assigned to receive either asundexian (50 mg once daily) or apixaban (5 mg twice daily, or 2.5 mg twice daily for those meeting two or more dose reduction criteria).

The OCEANIC-AF trial randomized patients to either the novel factor XIa inhibitor asundexian 50 mg once daily or apixaban 5 mg or 2.5 mg twice daily. The trial was terminated early because asundexian ...

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