Adenylosuccinate lyase deficiency (ADSLD) is a rare genetic disorder that affects purine metabolism, leading to various neurodevelopmental issues. Purines are essential building blocks for DNA and ...

Oral contraceptive pills (OCPs) are commonly used for contraception, but their long-term effects on oxidative stress, lipid profiles, and liver function remain unclear. This study aimed to evaluate ...

Conclusion Oxidative stress, especially through purine metabolism pathway, is a major metabolic event during reperfusion and may contribute to the ischaemia reperfusion injury of lung grafts. Data are ...

Metabolomic testing identified several differential serum metabolites, with alanine, aspartate, glutamate, glycerophospholipid, and tryptophan metabolism being the most important metabolic pathways.

The findings revealed that a wealth of metabolites was significantly altered after MDV infection and were linked to several key metabolic pathways, including alanine, aspartate, and glutamate ...

Uric acid is a waste product found in urine. If your body makes too much or doesn't eliminate enough of it, uric acid levels can become too high—a condition known as hyperuricemia. High uric acid ...

Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou 325000, China ...

Serum alanine transaminase (ALT), aspartate transaminase (AST), triglyceride (TG), cholesterol (TC), free ... RIPK1 is essential for the maintenance of hepatic homeostasis against the disturbance ...

Objective Liver injury impacts hepatic inflammation in part via Toll-like receptor (TLR) signalling. Triggering receptor expressed on myeloid cells 2 (TREM-2) modulates TLR4-mediated inflammation in ...