In assessing biological age, factors such as epigenetic changes, telomere length, oxidative damage, and mitochondrial dysfunction in rescue mechanisms such as autophagy all play major roles. Recent ...

What do cells do when they are “hungry”? Eukaryotic cells cope with starving conditions by eating their own components, a process called autophagy. Aa Aa Aa Normally, when you are hungry you ...

During starvation-induced autophagy, ATG2A undergoes depalmitoylation as the balance between ZDHHC11-mediated palmitoylation and APT1-mediated depalmitoylation. Inhibition of ATG2A depalmitoylation ...

2018). The proteins include: (4) Silent information regulator 1 (SIRT1) is a deacetylase that affects the activity of various transcription factors through deacetylation, thereby directly inducing the ...

The following answers to this artful question each win a random book. Art is something we do, a verb. Art is an expression of our thoughts, emotions, intuitions, and desires, but it is even more ...

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President Donald Trump has ordered federal officials to scour monuments, memorials and statues to remove language he says may "inappropriately disparage Americans," as part of his efforts to fight ...

自噬由多个阶段组成，启动阶段主要由 ATG1/ULK1 复合体调控，mTOR 激酶通过磷酸化 ULK1 和 ATG13 抑制自噬，而 AMPK 和 p53 信号则促进自噬。成核阶段由 VPS34—VPS15—Beclin-1 复合体驱动，该复合体有两种功能不同的形式，分别促进自噬体形成和成熟。延伸和闭合阶段由 ...