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探秘自闭症:药物治疗对大鼠模型端粒及相关基因的奇妙影响
为探究药物治疗对自闭症的作用机制,研究人员以丙戊酸(VPA)诱导的大鼠自闭症模型为对象,研究阿米替林、利培酮和诺氟沙星对端粒长度及端粒酶 / 庇护蛋白(shelterin)相关基因表达的影响。结果发现药物影响存在性别差异,这为理解自闭症神经生物学机制提供新视角。
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