Autophagy is a highly conserved mechanism for the survival of cells during times of metabolic stress. Autophagosomes form at points of contact between the endoplasmic reticulum (ER) and mitochondria, ...

Researchers at Zhejiang University found that acute stress increases natural repair mechanisms in the brain, while chronic ...

On the first day, the researchers found clear signs of stress. Cells showed an increase in proteins like p62, which typically accumulate when autophagy is disrupted. LC3-II, a marker of autophagic ...

近日，南方科技大学生命科学学院神经生物学系副教授赵燕课题组在国际学术期刊 Autophagy 上发表了题为“ATG2A acts as a tether to regulate autophagosome-lysosome fusion in ...

Day 7: Significant improvements emerged with increased LC3-II (a key autophagy marker), decreased p62, and normalization of cell death and inflammation signals. Laboratory experiments showed that ...

为探究阿卡西汀（ACA）对阿尔茨海默病（AD）的治疗潜力，研究人员开展了 ACA 对淀粉样 β（Aβ）肽诱导毒性模型中自噬通路和外泌体释放影响的研究。结果显示，ACA 能调节相关蛋白水平，减少 Aβ 和 Alix 蛋白量。这为 AD 治疗提供了新思路。

Usutu 病毒（USUV）严重影响鸟类和人类健康。为探究其与宿主细胞的相互作用机制，研究人员开展了关于 USUV NS4A 蛋白的研究。结果发现，USUV NS4A 诱导自噬，且被 p62/SQSTM1 靶向降解，这揭示了宿主抗病毒防御的新机制，为防控 USUV 感染提供新方向。

Edited by Ana Maria Cuervo, Albert Einstein College of Medicine, Bronx, NY; received June 7, 2024; accepted February 26, 2025 ...