Depression is one of the most common and disabling mental health conditions in the world, affecting over 10% of people ...

Several autophagy pathways operate within a cell, including macroautophagy, microautophagy and chaperone-mediated autophagy. Liver fibrosis is a consequence of the sustained inflammatory processes ...

By binding to an AKAP11 scaffold, PKA engages in poorly understood interactions with autophagy, a key degradation pathway for neuronal cell homeostasis. Mutations in AKAP11 promote schizophrenia and ...

AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) peptide has garnered attention for its intriguing biological properties ...

Researchers have identified a key enzyme driving forms of Parkinson’s, and have shown how blocking it restores normal ...

The Overholtzer lab studies mechanisms of nutrient sensing and cellular responses to nutrient starvation, including the nutrient recycling pathway autophagy, scavenging pathways such as ...

Researchers have identified a key enzyme driving forms of Parkinson's disease, and have shown how blocking it restores normal function in animal and cell models, offering a promising new drug target ...

Researchers at the University of Cologne found that mitochondrial dysfunction leads to early skeletal aging by disrupting ...

Researchers have discovered that a gene previously seen as a biomarker for Alzheimer’s disease, PHGDH, actually plays a ...

Nutrient timing may impact your metabolism and weight more than calorie count—here's how eating at the right time changes ...