Previous studies have indicated the roles of T cell-derived tumor necrosis factor-α (TNFα) and nuclear factor κB (NF-κB) signaling in tumor cell killing, with autophagy inhibiting TNF-α-induced ...

Autophagy is a process by which cellular material is degraded by lysosomes or vacuoles and recycled. Several autophagy pathways operate within a cell, including macroautophagy, microautophagy and ...

Background Fibrolamellar carcinoma (FLC), a rare and fatal liver cancer lacking effective drug therapy, is driven by the DNAJ ...

The tumor microenvironment is a harsh environment where metabolic adaptations are key. In this article, we explore how the ...

The University of Hong Kong, Hong Kong, Hong Kong.

A deeper understanding of osteosarcoma , the most common primary malignant bone tumor affecting children and adolescents, is ...

The lab also studies mechanisms that regulate autophagy protein and lysosome function in endocytic trafficking and nutrient homeostasis. Cell biologist Michael Overholtzer explores genes that make ...

前列腺癌严重威胁男性健康，现有治疗手段存在局限。研究人员聚焦分支链氨基酸（BCAAs）及 BCAT2 在前列腺癌中的作用。发现 BCAT2 高表达与预后不良相关，其通过与 PCBP1 互作调节 PI3K/AKT 通路，影响细胞进程。该研究为前列腺癌诊疗提供新靶点和思路。

New research shows caffeine supports blood vessel repair in lupus patients by boosting endothelial progenitor cell survival ...

口腔癌是常见的头颈部恶性肿瘤，五年生存率仅约 50 - 60%。为探究程序性细胞死亡（PCD）在口腔癌中的作用，研究人员通过文献计量分析 2000 - 2024 年相关文献。结果显示研究呈增长趋势，发现新热点和方向。这为口腔癌研究提供参考，助力开发新疗法。