High-grade glioma, an aggressive form of pediatric and adult brain cancer, is challenging to treat given the tumor location, ...

Scientists performed a first-ever clinical test of the therapy avapritinib in pediatric patients with high-grade glioma. They ...

An international team of clinical collaborators, led by physician scientists from Dana-Farber Cancer Institute, performed a first-ever clinical test of the targeted therapy avapritinib in pediatric ...

Avapritinib, an FDA-approved drug used to treat other types of cancer, also decreases aggressive gliomas in animal models and ...

本文研究发现 Avapritinib 对 PDGFRA 改变的儿童高级别胶质瘤（HGG）有治疗潜力，值得关注。 ### 儿童高级别胶质瘤治疗现状与挑战 儿童高级别胶质瘤（pediatric high-grade gliomas，pHGGs），如 H3K27M 弥漫性中线胶质瘤（diffuse midline gliomas，DMGs），是一类致命的疾病 ...

We were excited to see that avapritinib essentially shut off PDGFRA signaling in mouse brain tumors." Carl Koschmann, M.D., ChadTough Defeat DIPG Research Professor and clinical scientific ...

An international team of clinical collaborators, led by physician scientists from Dana-Farber Cancer Institute, performed a ...

A study shows that high-grade glioma tumor cells harboring DNA alterations in the gene PDGFRA responded to the drug avapritinib, which is already approved by the United States Food and Drug ...