In BrdU incorporation assays cells were stained with mAbs for B220 and CD19, then fixed, permeabilized, treated with DNase. Subsequently, cells were stained with anti-BrdU-FITC mAb according to the ...

CD19 + 成熟 B 细胞增多，这一系列变化都表明重归自然促进了 B 细胞的成熟。在骨髓中，虽然 B 细胞比例有所下降，但 B220 hi IgM + 循环成熟 B 细胞数量和其与未成熟 B 细胞的比例均增加，进一步证实了 B 细胞成熟的加速。 生发中心（GC）反应增强：在对脾脏和 ...

为解决 CAR-T 细胞疗法成本高、生产受限等问题，研究人员开展了利用睡美人（SB）转座子工程化供体来源的抗 CD19.CD28.OX40.CD3ζ T 细胞（CAR CIK-CD19）治疗异基因造血干细胞移植（alloHSCT）后复发的 B 细胞前体急性淋巴细胞白血病（BCP-ALL）的研究。结果显示该疗法 ...

Building on its autologous CD19 CAR-T cell therapy obe-cel, Autolus added a CD22 CAR to create AUTO1/22. The dual mechanism is intended to address a major cause of treatment failure. Thursday ...

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Background and aim: Long term high-dose erythropoietin (EPO) had been reported inducing the formation of abdominal aortic aneurysm (AAA) in mice. When using this model, we found that EPO treated mice ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Syndecans (SDCs) are ...

1Children’s Research Institute and the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas. 10Howard Hughes Medical Institute, UT Southwestern Medical Center, ...