Gut Microbiota in Immuno-Oncology: A Practical Guide for Medical Oncologists With a Focus on Antibiotics Stewardship Bispecific antibodies (bsAbs) have emerged as a novel class of therapeutics, ...

PRESENTED at EBMT 2025 Annual Meeting, this study investigated the role of functional respiratory tests (FRT) in screening patients before anti-CD19 CAR-T cell therapy, focusing on their impact on ...

Inebilizumab is a monoclonal antibody that depletes CD19+ B cells, which are central to disease pathogenesis. In this phase 3, double-blind, randomized, placebo-controlled trial, we enrolled ...

From the Department of Cardiology and Angiology I, University Heart Center Freiburg, Germany (D.W.) Faculty of Medicine, University of Freiburg, Germany (D.W.) K. Ley has received research funding for ...

1Children’s Research Institute and the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas. 10Howard Hughes Medical Institute, UT Southwestern Medical Center, ...

SMAD4 基因敲除使多种 NK 细胞平台对 TGFβ 具有抗性，包括 CD19-CAR NK 细胞、干细胞来源的 NK 细胞和 ADAPT-NK 细胞。 总的来说，这些发现表明，敲除 SMAD4 ...

热门靶点竞争激烈，以CD19，BCMA，FAP为靶点的产品正在逐年增加。 大量的企业涌入同一赛道，会造成无价值的同质化研发。而由于生物医药的研发 ...

例如，用编码 CAR 的信使 RNA（mRNA）瞬时转染 T 细胞，使 CAR 蛋白表达随 T 细胞增殖而减少；调整 CAR 与抗原的亲和力，如 CAT CAR 对 CD19 的亲和力比 FMC63 CAR 低至少 40 倍，但抗肿瘤活性更强且神经副作用更轻。 主动控制 - “关闭开关”：利用自杀基因，如单纯疱疹 ...

Poor physical performance in patients with non-Hodgkin lymphoma receiving CAR T-cell therapy was linked to worse survival and increased risk of neurotoxicity in a cohort study.

The South San Francisco-based company continued its pivot from oncology to autoimmune disease last year by halting work on the allogeneic CD19-directed CAR NK, dubbed NKX019, in lymphoma to focus ...

Background: Anti-CD19 chimeric antigen receptor T (CAR-T) cell therapy has proven effective for treating relapsed or refractory acute B cell leukemia. However, challenges such as cytokine release ...