BRAF, a member of a serine/threonine kinase protein family, serves as an immediate downstream effector of RAS in the MAPK signaling cascade, a signal transduction pathway that transmits mitogenic ...

Verastem Oncology (Nasdaq: VSTM), a biopharmaceutical company committed to advancing new medicines for patients with RAS/MAPK ...

BRAF gene fusions are much more common than BRAF ... it has two other assets in early development that target the BRAF-MAPK signalling pathway, including IPN01194 that started phase 1 earlier ...

Black Diamond Therapeutics has found a partner for its deprioritized solid tumor candidate. Five months after cutting support ...

One of the standard treatment options for melanoma over the last ten years has been to simultaneously target both BRAF mutations and MEK. These two genes are part of the MAPK signalling pathway ...

[email protected] Cytological fine-needle aspiration diagnosis of thyroid nodules can be improved by testing for BRAF, RET/PTC and other mutations. BRAF is a reliable diagnostic marker for ...

BRAF, and CRAF, potentially creating a more complete and durable anti-tumor response through maximal RAS/MAPK pathway inhibition. In contrast to currently available MEK-only inhibitors ...