including cancer cells, to repair DNA damage, in men with BRCA1 genetic variants, say the researchers. A linked editorial suggests that the findings pave the way for greater refinement of genetic ...

Whalen, PhD, poses a new explanation for how cancer-fighting drugs attack and destroy BRCA1 and BRCA2 tumor cells. Published in Nature Cancer, their work illustrates how a small DNA nick—a break in ...

including cancer cells, to repair DNA damage, in men with BRCA1 genetic variants, say the researchers. A linked editorial suggests that the findings pave the way for greater refinement of genetic ...

Whalen, Ph.D., poses a new explanation for how cancer-fighting drugs attack and destroy BRCA1 and BRCA2 tumor cells. Their work, published in Nature Cancer, illustrates how a small DNA nick—a ...

Opens in a new tab or window We followed 25,811 females and 480 males diagnosed with BC and tested for germline BRCA1/BRCA2 PVs in NHS Clinical Genetics centers in England between 1995 and 2019 ...

Discover the intricate dance between genes, environment, and cancer risk explained by Dr. Ashok Venkitaraman in a ...

The BRCA1 (breast cancer gene one ... The PIK3CA gene gives instructions to make a protein that’s important for many cell functions. A PIK3CA mutation isn’t inherited – you can’t pass ...

Cells normally use highly accurate mechanisms to fix these breaks, but some cancers -- particularly those arising from BRCA1 or BRCA2 mutations, such as certain breast and ovarian cancers -- lack ...