Depletion of any non-BRCA1 component compromised the formation of DNA damage-induced BRCA1 foci. By contrast, BRCA1 depletion does not affect the localization of the other components of the ...

As a young breast cancer survivor with a BRCA1-positive diagnosis, I faced tough choices. Ultimately, I chose to undergo a laparoscopic prophylactic oophorectomy, a decision rooted in my ...

Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key to the initiation of prostate cancer, as previously thought, suggests the first study of its ...

In high-income countries, most patients with a DNA repair deficiency known as HRD—which can be caused by BRCA1 or BRCA2 ...

Sensitivity to ionizing radiation is compelling evidence that BRCA1-and BRCA2-deficient cells are defective in repair of DSBs. As discussed above, 2 separate pathways play major roles in DSB repair in ...