ELF3 can help suppress excessive genomic instability and promote LP transformation with BRCA1 deficiency. Moreover, ELF3 emerged as a core transcription factor regulating LP genes, leading to LP ...

Jan. 30, 2025 — A research group has developed new advanced light-controlled tools that enable precise control of proteins in real time in living cells. This groundbreaking research opens doors ...

The screening programme looks for mutations in the BRCA genes which push up a person’s risk of cancer. Everyone has BRCA1 and BRCA2 genes, but people who have changes in the gene are at higher ...

The manuscript focuses on a persistent question of why germline mutations in BRCA1 which impair homology-directed repair of DNA double-strand breaks predispose to primarily breast and ovarian cancers ...

Jan. 30, 2025 — A research group has developed new advanced light-controlled tools that enable precise control of proteins in real time in living cells. This groundbreaking research opens doors ...

The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and ...

Scientists led by a team at Columbia University have trained a model to predict how the genes inside a cell will drive its behavior, which could be a powerful tool with the potential to broaden ...

DNA is organized in segments on chromosomes called genes. Humans typically have 46 chromosomes arranged in 23 pairs. Genetics plays a key role in answering each of these questions. For humans ...