EurekAlert!1 个月
BRCA1 gene mutations may not be key to prostate cancer initiation, as previously thought
Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key to the initiation of prostate cancer, as previously thought, suggests the first study of its ...
来自MSN1 个月
BRCA1 gene mutations may not be key to prostate cancer initiation, as previously thought
The men had either been tested for germline (166), somatic (280), or both types (four) of genetic variants of BRCA1, BRCA2, ATM, CDK12, and PALB2 genes, with a view to starting them on PARP ...
Nature6 年
Higher-order BRCA1 complexity
The breast cancer susceptibility gene 1 (BRCA1) protein forms complexes with other protein components to regulate the cellular response to DNA damage. Three studies now report the identification ...
来自MSN4 个月
Research shows how even one faulty copy of the BRCA1 gene can fuel breast cancer
People inherit two copies of each gene—one from each parent—an evolutionary fail-safe to ensure survival even when one of them doesn't function. For cancer-suppressor genes like BRCA1 ...
Jewish Telegraphic Agency5 年
Ashkenazi Jewish women should be screened for breast cancer genes, US task force says
Primary care doctors should assess women’s BRCA1 and BRCA2 mutation risks ... It also called for an increase in the number of cancer-specific genetic counselors in the United States.