Breast cancer is the most commonly diagnosed cancer among women in the U.S. and is currently one of the leading causes of ...

The breast cancer susceptibility gene 1 (BRCA1) protein forms complexes with other protein components to regulate the cellular response to DNA damage. Three studies now report the identification ...

Women with a BRCA1 or BRCA2 mutation have up to a 72% chance of breast cancer during their lifetime. Normally, the PALB2 gene makes a protein that works with the BRCA2 gene protein to repair ...

Triple negative breast cancer accounts for 15% of cases but causes a disproportionate number of deaths. Learn about symptoms and treatments.

Technically, Pol-theta is an enzyme -- a type of protein that speeds up chemical ... but some cancers -- particularly those arising from BRCA1 or BRCA2 mutations, such as certain breast and ...

Targeting BRCA1-deficient PARP inhibitor-resistant cells with nickases reveals nick resection as a cancer vulnerability. Nature Cancer , 2025; 6 (2): 278 DOI: 10.1038/s43018-024-00902-1 Cite This ...

owing to dysfunction of the breast cancer type 1 susceptibility protein (BRCA1). Indeed, mutations in BRCA1 are known to predispose individuals to hereditary breast and ovarian cancers.

Sensitivity to ionizing radiation is compelling evidence that BRCA1-and BRCA2-deficient cells are defective in repair of DSBs. As discussed above, 2 separate pathways play major roles in DSB repair in ...