为改善晚期胃癌治疗现状，研究人员开展靶向 BCL XL 和 MCL 1 的研究，发现联合抑制可增强抗癌活性。 胃癌是全球第五大常见且致命的癌症，多数晚期患者预后差，现有治疗手段效果不佳。为了找到更有效的治疗策略，中国医学科学院 & 北京协和医学院的研究人员 ...
Abstract: The overexpression of B-cell lymphoma-extra large (BCL-xL), an anti-apoptotic protein, plays a pivotal role in various cancers by inhibiting apoptosis and promoting tumor progression. We ...
1Division of Medical Oncology, Department of Medicine, School of Medicine, Washington University in St. Louis, St. Louis, Missouri.
A recent study published on January 31, 2024, in Nature Aging introduces a potential new drug that could help. Scientists believe this drug can remove harmful “zombie” cells from the liver and slow ...
《自然·衰老》杂志发表的一项研究揭示了一种有前景的新药物候选物，可能有助于对抗代谢功能障碍相关脂肪性肝病（MASLD）。这种慢性肝病在圣安东尼奥社区中尤为常见，因为该地区肥胖和糖尿病的发病率较高。该病可能导致严重的并发症，如肝纤维化、肝硬化和肝癌，是一个重大的公共卫生挑战。
News Medical on MSN8 天
New drug candidate may help combat metabolic dysfunction-associated steatotic liver diseaseA study published in Nature Aging has revealed a promising new drug candidate that may help combat metabolic dysfunction-associated steatotic liver disease (MASLD), a chronic liver condition that ...
The new drug candidate developed in this study targets two proteins, BCL-xl and BCL-2, that help senescent cells avoid death, thus promoting MASLD progression. By degrading these proteins ...
Bcl - 2 家族蛋白分为抗凋亡蛋白（如 Bcl - 2、Bcl - XL 等）和促凋亡蛋白（如 Bax、Bak、Bim 等） 。Bim BH3 可以与抗凋亡的 Bcl - 2 家族蛋白（如 Bcl - 2、Bcl - XL ）的疏水口袋特异性结合，从而破坏抗凋亡蛋白的功能 。这种结合阻止了抗凋亡蛋白对促凋亡蛋白 Bax 和 Bak 的 ...
Cpm - 1285 是一种设计用于靶向并抑制 Bcl - 2 家族蛋白的合成多肽 。它通过化学连接脂肪酸到来源于促凋亡蛋白 Bad 的肽段上而得 。这种结构设计赋予了它一些独特的性质 。从整体结构上看，脂肪酸部分可能有助于其穿透细胞膜，进入细胞内部发挥作用 。其 ...
The new drug candidate developed in this study targets two proteins, BCL-xl and BCL-2, that help senescent cells avoid death, thus promoting MASLD progression. By degrading these proteins ...
BCL Industries Ltd., incorporated in the year 1976, is a Small Cap company (having a market cap of Rs 1,196.30 Crore) operating in Agro Processing sector. BCL Industries Ltd. key Products/Revenue ...
The P/B ratio shows how a stock's market price compares to its book value. It helps gauge whether a stock is undervalued or overvalued relative to its net assets.
一些您可能无法访问的结果已被隐去。
显示无法访问的结果
反馈