Targeting bile acid signaling pathways shows promise as a potential treatment approach for these diseases. However, further research is needed to understand the underlying mechanisms. Scientists ...

However, there is still a big gap in knowledge about the association between gut microbiota associated metabolism alterations and GDM development ... sequencing and high-performance liquid ...

Results: Untargeted metabolomics revealed that, after SY009 treatment, there were differences in metabolic pathways, including primary bile acid biosynthesis; biosynthesis of unsaturated fatty acid; ...

Scientists seek advanced technologies to better understand these metabolites and their influence on health. Thomas Horvath: Bile acids are cholesterol-derived compounds essential for digesting lipids ...

focusing on their ability to modulate metabolic processes and influence inflammation. This growing interest is driven by the recognition that bile acids can affect various cellular pathways ...

INTERPRETATION/SUMMARY These results: (i) confirm that there are marked regional differences in bile acid metabolism between the right and left halves of the colon ... in significantly reduced amounts ...

More information: Siva Karthik Varanasi et al, Bile acid synthesis impedes tumor-specific T cell responses during liver cancer, Science (2025). DOI: 10.1126/science.adl4100 ...

They do all this by binding to a receptor called FXR, which acts like a traffic light, controlling cholesterol metabolism and bile acid production to avoid excess buildup." Here's where the ...

This helps improve fat metabolism by aiding in the breakdown and processing of fat. When gut bacteria produce large amounts of bile acids that activate FXR and reduce bile production, the body ...

Immunohistochemistry and in situhybridisation were used to detect the expression of selected miRNAs and their targets in IM tissue microarrays. Results We demonstrate a bile acids-triggered pathway ...

Diabetes, a common metabolic condition ... and insulin signaling pathways. Despite being in early research stages, bile acid receptor agonists and mitochondrial uncouplers have promising potential ...