This manuscript demonstrates that Oct4 overexpression synergizes with Notch inhibition (Rbpj knockout) to promote the conversion of adult murine Müller glia (MG) into bipolar cells. These findings are ...

exerts an antimanic effect in a mouse model of mania. Zarate et al. have now examined the effect of tamoxifen in a double-blind pilot trial of 16 inpatients in the manic phase of bipolar disorder.