Dec. 10, 2024 — In a single IV injection, a gene therapy targeting cBIN1 can reverse the effects of heart failure and restore heart function in a large animal model. The therapy increases the ...

Gene regulation refers to the mechanisms that act to induce or repress the expression of a gene. These include structural and chemical changes to the genetic material, binding of proteins to ...

as there was no uniform standard of reliable methods for the clear characterization of these starting points for the ribosome-mediated control of gene expression. Researchers have now ...

该研究成果发表在《Cancer Gene Therapy》杂志上。 研究人员在实验过程中运用了多种关键 ... 且对 miR-15 家族预测靶标的下调程度相近。不过，共识模拟物在降低 CCND1 mRNA 表达方面比 miR-16 更有效，这可能是因为其与 CCND1 3′非翻译区（3′UTR）靶位点的结合自由能 ...