在免疫系统中，免疫耐受的失衡是过敏性哮喘的关键致病因素。不同类型的细胞参与维持免疫耐受，其中 CD4? CD44?记忆 T 细胞与免疫耐受关系密切，而组织驻留记忆 T（TRM）细胞又是 CD4? CD44?记忆 T 细胞的重要亚型。不过，TRM 细胞在哮喘免疫耐受中的作用以及其受 ...

Researchers investigating the role of the protein CD44 in obesity and metabolic health found that CD44-deficient mice stayed lean even on a high-fat diet, while the control mice developed obesity.

The decrease in CD4 cells during HIV infection seems to be driven by immune activation, which does not always correlate with viral load. Experienced clinicians are all too familiar with the ...