在免疫系统中，免疫耐受的失衡是过敏性哮喘的关键致病因素。不同类型的细胞参与维持免疫耐受，其中 CD4? CD44?记忆 T 细胞与免疫耐受关系密切，而组织驻留记忆 T（TRM）细胞又是 CD4? CD44?记忆 T 细胞的重要亚型。不过，TRM 细胞在哮喘免疫耐受中的作用以及其受 ...

(H) SBP and UACR of pregnant mice injected with PBS, Sham mouse-derived or RUPP mouse-derived CD4 + CD44 + T cells. Data were compared between groups using one-way ANOVA and represented as mean±SEM ...

Researchers investigating the role of the protein CD44 in obesity and metabolic health found that CD44-deficient mice stayed lean even on a high-fat diet, while the control mice developed obesity.

点击蓝字关注我们【导读】癌症治疗的临床方法面临着几个相互关联的挑战，包括药物输送效率低、潜在的不良副作用和不便。2025年3月18日，四川大学/华西医院的研究团队在期刊《Nature Communications》上发表了题为“Wearable ...

Mononuclear cells were prepared by using Ficoll (Cytiva, USA) gradient centrifugation, stained with Fixable Viability Stain 700 (BD Biosciences, USA) and fluorochrome-conjugated antibodies CD3-APC-Cy7 ...

细胞增殖的周期性是生物的一个基础特征。同样适应性免疫的抗原特异性T和B细胞通过克隆扩增产生大量短寿命的效应细胞和一些长寿命的记忆细胞。T细胞主要有两个亚群：辅助性CD4T细胞和细胞毒性CD8T细胞；随着时间推移，记忆性CD4+T和CD8+T通过细胞死亡、存活 ...

GLP-1RA could not only facilitate the M2 polarization of microglia through both direct and indirect pathways, but also modulate the quantity and function of T cell subtypes, including CD4, CD8, and ...

The decrease in CD4 cells during HIV infection seems to be driven by immune activation, which does not always correlate with viral load. Experienced clinicians are all too familiar with the ...