为解决免疫疗法（如免疫检查点抑制剂 ICIs）缺乏有效预后生物标志物的问题，研究人员开展了关于癌症干细胞标志物 CD44 在 33 种人类癌症中预后价值及免疫功能的研究。结果发现 CD44 与肿瘤分期、预后及免疫微环境相关，可作为潜在免疫治疗靶点和生物标志物。

Various T cell subsets were further analyzed: from CD3e+ gate, CD4+ T cells, CD8+ T cells, CD3e+CD44+CD69+ (T cell+Trm+), CD3e+CD4+CD44+CD69+ (CD4 Tcells+Trm+), and CD3e+CD8+CD44+CD69+ (CD8 T ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Rheumatoid arthritis (RA) is associated with ...

Background: Cell-mediated immunity may provide durable protection against severe COVID-19, including among solid organ transplant recipients (SOTRs). This exploratory analysis in the open-label phase ...

推荐阅读！本文聚焦肥胖与胰岛素抵抗难题，发现 CD4 + T 细胞分泌的硬化蛋白域包含蛋白 1（SOSTDC1）显著影响疾病进程。SOSTDC1 通过 LRP5/6-β-catenin 通路调控脂肪代谢，T 细胞受体（TCR）信号可增强其分泌。抑制 SOSTDC1 或成代谢疾病新疗法。 ### 研究背景 全球肥胖 ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. In response to infections, naive CD8 T cells ...