为解决免疫疗法（如免疫检查点抑制剂 ICIs）缺乏有效预后生物标志物的问题，研究人员开展了关于癌症干细胞标志物 CD44 在 33 种人类癌症中预后价值及免疫功能的研究。结果发现 CD44 与肿瘤分期、预后及免疫微环境相关，可作为潜在免疫治疗靶点和生物标志物。

T cells are a type of white blood cell that is central to your immune defense. Four types that serve different functions include: CD4 and CD8 are two different types of glycoprotein found on the ...

From the Department of Cardiology and Angiology I, University Heart Center Freiburg, Germany (D.W.) Faculty of Medicine, University of Freiburg, Germany (D.W.) K. Ley has received research funding for ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. In response to infections, naive CD8 T cells ...

Stages of HIV Infection The stages of infection from person to person vary slightly, both in severity and the speed of progression. These stages map the depletion of CD4 T-cells and other evidence of ...

研究结果表明阻断TfR可以抑制肺腺癌的进展，说明转铁蛋白受体是肺腺癌的治疗靶点。 CD44是一种复杂的跨膜黏附糖蛋白，在多种细胞和组织表面广泛表达，研究发现CD44在肺癌组织中高度表达，又因为其是多种肿瘤干细胞的标志物，故CD44是潜在的肿瘤治疗靶点[41]。

The clinical trial, dubbed FRESH and conducted in Durban, South Africa, revealed that four out of 20 women with acute HIV infection have remained off antiretroviral therapy for approximately 18 months ...

在免疫系统中，免疫耐受的失衡是过敏性哮喘的关键致病因素。不同类型的细胞参与维持免疫耐受，其中 CD4? CD44?记忆 T 细胞与免疫耐受关系密切，而组织驻留记忆 T（TRM）细胞又是 CD4? CD44?记忆 T 细胞的重要亚型。不过，TRM 细胞在哮喘免疫耐受中的作用以及其受 ...

(H) SBP and UACR of pregnant mice injected with PBS, Sham mouse-derived or RUPP mouse-derived CD4 + CD44 + T cells. Data were compared between groups using one-way ANOVA and represented as mean±SEM ...

The data analysis is rigorous and the experiments performed are appropriate. The findings of the manuscript will expand upon previous findings of a role for histone deacetylase 3 in thymocyte ...