Researchers investigating the role of the protein CD44 in obesity and metabolic health found that CD44-deficient mice stayed lean even on a high-fat diet, while the control mice developed obesity.

Processes such as mitochondrial fission, fusion, mitophagy, changes in membrane potential, reactive oxygen species (ROS) accumulation, and oxidative phosphorylation (OXPHOS) are all linked to drug ...

Sarcomas are generally classified into soft tissue sarcomas, such as fibrosarcoma, and bone sarcomas such as chondrosarcoma, which are rare cancers in adults accounting for about 1% of all cancer ...

为解决急性肾损伤（AKI）机制不明及治疗策略缺乏的问题，南方医科大学研究人员探究 CD44 在 AKI 中的作用。结果发现 CD44 可加重 AKI，抑制它或成治疗新策略。推荐科研读者阅读，以了解 AKI 新机制与潜在疗法。 在当今社会，急性肾损伤（AKI）就像一个隐藏在 ...

Ischemic heart disease (IHD) is a leading cause of disability and death worldwide, with immune regulation playing a crucial role in its pathogenesis. Various immune cells are involved, and as one of ...

而且，抑制 OXPHOS 会显著增加乳腺球中死亡细胞的比例 ... 他们发现，在患者来源的肿瘤球中，YAP/TAZ 与 SOX2 在 CD44?/CD24?细胞的细胞核内存在相互作用。沉默 YAP/TAZ 会导致 SOX2 及其下游靶基因的表达降低，肿瘤球的形成效率和 CD44?/CD24?细胞群体减少，ROS 水平升高 ...

细胞增殖的周期性是生物的一个基础特征。同样适应性免疫的抗原特异性T和B细胞通过克隆扩增产生大量短寿命的效应细胞和一些长寿命的记忆细胞。T细胞主要有两个亚群：辅助性CD4T细胞和细胞毒性CD8T细胞；随着时间推移，记忆性CD4+T和CD8+T通过细胞死亡、存活 ...