NiKang Therapeutics has concluded the first cohort dosing in the open-label Phase I trial of NKT3964 as a monotherapy for treating adults with advanced or metastatic solid tumours. The dose-escalation ...

为探究 MEF2C 调节小胶质细胞激活机制，研究人员开展相关研究，发现该通路及 CDK2 抑制剂作用，意义重大。 小胶质细胞内在免疫检查点是维持免疫稳态的重要保障，能防止小胶质细胞过度激活，这一过程对自闭症谱系障碍（ASD）等神经系统疾病影响显著。

2025 年 3 月 25 日清华大学药学院丁胜教授团队在 Immunity 期刊发表文章揭示了Mef2C作为小胶质细胞检查点的具体分子机制，并进一步发现CDK2抑制剂BMS ...

STIL is recruited by CEP131, which gets phosphorylated by Polo-like kinase 4 (PLK4) and is responsible for regulating the centriole positioning of Cyclin-dependent kinase 2 (CDK2). CDK2 binds to its ...

Plants are very important living things. They have lots of jobs, such as providing animals with food and releasing oxygen into the air. To survive and carry out these jobs, they all need three ...

Computer-Aided Drug Design (CADD) is an area of science that is rapidly growing, involving using computers to discover and design new drugs. CADD focuses on understanding the three-dimensional ...

Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States ...

The Wang 2015 data set consists of 8 target proteins, each with a series of ligands [1]. Each target contains a single protein structure and multiple ligands. There are two complete set of modeled ...