Gene expression testing helps determine chemotherapy needs for hormone receptor-positive breast cancer, optimizing treatment ...

Using an unbiased approach, this important study discovered a role of Ezh2 in the differentiation of granule neuron precursors, the cell of origin for Shh group of medulloblastoma. Furthermore, the ...

Dr. Kevin Kalinsky covers the gamut of the current treatment landscape for patients with HER2-negative breast cancer, ...

近年来，细胞周期蛋白依赖性激酶 4/6（CDK4/6）抑制剂联合内分泌治疗已成为 HR+/HER2- 晚期乳腺癌的一线标准治疗。然而，耐药性的出现限制了其临床 ...

Camizestrant combined with CDK4/6 inhibitors improved progression-free survival in HR+/HER2- advanced breast cancer with ESR1 mutations in the SERENA-6 trial. In the phase 3 SERENA-6 trial ...

Dec. 10, 2024 — In a single IV injection, a gene therapy targeting cBIN1 can reverse the effects of heart failure and restore heart function in a large animal model. The therapy increases the ...

Multiple novel agents with diverse mechanisms of action are currently in development to overcome resistance to endocrine therapy (ET) and CDK4/6 inhibitors in hormone receptor–positive breast cancer.

NEW YORK – AstraZeneca on Wednesday said it will share with regulators interim data from a Phase III trial showing that camizestrant plus a CDK4/6 inhibitor bested standard treatment with aromatase ...

Atirmociclib作为一种CDK4选择性抑制剂，与现有的CDK4/6抑制剂哌柏西利相比，其在结构上对CDK4的亲和力更高，选择性更强。 细胞 ...

Why do medications that are supposed to help patients with chronic inflammatory diseases sometimes lead to blood clots?

Gene was suffering from severe heart disease and advanced Alzheimer's disease, while Betsy suffered from hantavirus, which is spread through rodent droppings Gene Hackman's wife Betsy Arakawa ...