Further investigation into the role of CDK4/CDK6 in ESCC was conducted through CRISPR-mediated gene knockout experiments. The depletion of CDK4/CDK6 in ESCC cells not only reduced their ...

and CDK4" has been published in Genes & Cancer. The MYC gene is a regulatory and proto-oncogenic gene that is overexpressed in the majority of prostate cancers (PCa). Numerous studies have ...

Cyclin D, encoded by the CCND1 gene, has already given rise to a class of widely used breast cancer drugs known as CDK4/6 inhibitors. Compared with targeting cyclin D and CDK4/6, which are ...

often combined with CDK4/6 inhibitors; however, many patients with advanced disease develop resistance to these therapies. Mutations in the ESR1 gene are a major driver of endocrine resistance and are ...

Gene expression testing helps determine chemotherapy needs for HR+ breast cancer, optimizing treatment and reducing ...