Dr. Sara M. Tolaney discusses breast practices associated with CDK4/6 inhibitors for the treatment of breast cancer. At the 42nd Annual Miami Breast Cancer Conference, Dr. Sara M. Tolaney sat down for ...

图 1. CSCO 乳腺癌诊疗指南（2024 版） CDK4/6 抑制剂如今已成为激素受体阳性晚期乳腺癌标准一线治疗方案。随着其大幅降价进入医保，这几年临床越 ...

近年来，细胞周期蛋白依赖性激酶 4/6（CDK4/6）抑制剂联合内分泌治疗已成为 HR+/HER2- 晚期乳腺癌的一线标准治疗。然而，耐药性的出现限制了其临床 ...

Our drug discovery model has identified two novel STAT3 SH2 domain inhibitors 323–1 and 323–2 (delavatine A stereoisomers) in a series of experiments. In silico computational modeling, drug affinity ...

"In the amygdala, the gene Stat3 is involved in the regulation of blood pressure and possibly plays a role in blood pressure elevation in response to chronic stress. It might also be involved in ...

Background: circHIPK3 role in cancer as oncogene or tumor suppressor is still debated, therefore, this study aimed to understand the dual role of this circRNA in different cancers. Furthermore, all ...

On the plus side, CDK4/6 inhibitor Verzenio (abemaciclib) grew 68% in the three-month period to top $1 billion, fuelled by expanded use in early-stage breast cancer. Novo Nordisk's obesity ...

Our aim was thus to clarify the role of STAT3 during fetal lung development. Materials and Methods The STAT3 expression pattern was assessed by immunohistochemistry. Rat lung explants were harvested ...