The authors have generated important resources such as a reference dataset of early primate development by utilizing single-cell transcriptomic technology together with induced pluripotent stem cells ...

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Objective Liver injury impacts hepatic inflammation in part via Toll-like receptor (TLR) signalling. Triggering receptor expressed on myeloid cells 2 (TREM-2) modulates TLR4-mediated inflammation in ...

进一步研究发现，CS-IVa 可下调 Yes 相关蛋白（YAP）和 Tafazzin（TAZ）表达，抑制 YAP/TAZ 通路，减少肝组织中 α - 平滑肌肌动蛋白（α-SMA）和胶原蛋白 α1 (I) 链（COL1A1）的表达，从而减轻肝纤维化。 在体外实验中，研究人员用转化生长因子 β1（TGF-β1）刺激 LX-2 细胞 ...

这些炎症因子通过旁分泌作用影响 HFF，降低线粒体膜电位，增加线粒体 ROS 水平，下调 TGF-β 1-Smad2/3 信号通路，增加 β-Gal 活性，减少 COL1A1 和 COL3A1 表达，促使 HFF 老化。而刺梨提取物可通过下调角质形成细胞的 IL-17 通路，抑制炎症反应，减轻对 HFF 的旁分泌 ...

Department of Physiology, Saha Cardiovascular Research Center, Saha Aortic Center, University of Kentucky (A.D., H.S.). Division of Medical Genetics, Department of ...