为探究植物系统生产生物仿制药的潜力，研究人员开展表达抗人 CTLA-4 抗体伊匹木单抗（Ipilimumab）的研究。结果显示，纯化的 mAb P CTLA-4 能有效识别 CTLA-4，这表明植物表达系统在生产高价值药用生物仿制药方面潜力巨大。 在癌症治疗领域，免疫疗法近年来备受 ...

该研究为理解免疫调节机制提供新视角。 细胞毒性 T 淋巴细胞相关抗原 - 4（CTLA-4）是一种共抑制受体，可限制 T 细胞激活。CTLA-4 有膜结合型（mCTLA-4）和可溶性（sCTLA-4）两种形式，但 sCTLA-4 的主要产生细胞、动力学和功能尚不清楚。在此，研究人员探究了 sCTLA-4 ...

Abatacept was not associated with an increased risk for malignancy in patients with rheumatoid arthritis or psoriatic arthritis based on clinical trial data, though observational data differed. Study ...

研究者优化了血浆蛋白质组分析管道，并为DBT队列提供了蛋白质组数据集。通过整合临床和蛋白质组数据，挖掘了关键的候选生物标志物PA、LDH和APOC3 ...

The Witcher 4 has now been officially revealed, with a new trailer confirming that the game will focus on Ciri as the main protagonist. This latest look does give us an idea as to the overall ...

Frank Cottrell-Boyce and Cressida Cowell recommend a selection of children’s books.

We may not all find the same things funny but all cultures in the world laugh. Why do we love dogs? Dogs evolved from wolves but why did they choose us humans to be their best friends? 10 Places ...

When is The Witcher 4 release date? CD Projekt Red initially confirmed the existence of a new game in The Witcher series via a press release in March 2022 and a title update in October 2022.

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Sonic 4 is in the works, with a release date already set for the sequel. It's a few years away, but that's OK, because even speedy hedgehogs and their pals need to pace themselves. Following the ...

In cancer, tremendous efforts have been made to understand and antagonize classic T cell checkpoint molecules such as PD-1 and CTLA-4 with the aim of untethering adaptive immune responses against ...