Figure 3: Overall structure of the β-catenin-E-cadherin complex. At the atomic level, these interactions include salt bridges, hydrophobic interactions and an extensive network of hydrogen bonds.

The whole P-cadherin/antibody/drug complex is then sent to a structure called the lysosome to be broken down. "Our results establish an outside-in signaling mechanism that provides fundamental ...

targeting cadherin-17 (CDH17). The data highlight SOT109's promising activity and tolerability profile across multiple disease models, reinforcing its potential to become a best-in-class ...