The study represents the first attempt to explore the role of T-cadherin in COVID-19 pathogenesis as well as its implications in pulmonary fibrosis and endothelial dysfunction. First, we revealed a ...

Beyond providing a proof of concept, our findings also provide new mechanistic insights into the functionality of ROCK inhibitors in VE cadherin–mediated cell–cell junctions, elucidating how they can ...

Scientists are working across disciplines to render complex reality to scientific understanding. It has been the great triumph of the sciences to find consistent means of studying phenomena hidden by ...

We show that cadherin-mediated cell–cell adhesion regulates differential cellular responses to compressive stress and is an important driver of unjamming in stressed monolayers. Importantly, ...

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targeting cadherin-17 (CDH17). The data highlight SOT109's promising activity and tolerability profile across multiple disease models, reinforcing its potential to become a best-in-class ...

The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.biomac.4c01579. LC–MS analysis data, optical images of the cations ...

Correspondence to Dr Jun Yu, Institute of Digestive Disease and The Department of Medicine and Therapeutics, Chinese University of Hong Kong, New Territories, Hong Kong; junyu{at}cuhk.edu.hk The gut ...

Additionally, mesenchymal markers like Vimentin and α-SMA were also diminished, while epithelial markers such as E-cadherin, Occludin, and ZO-1 were elevated, suggesting a disrupted EMT process.

The authors have generated important resources such as a reference dataset of early primate development by utilizing single-cell transcriptomic technology together with induced pluripotent stem cells ...