Hosted on MSN1mon
Antibody's outside-in signaling shows a route into cancer cells
The whole P-cadherin/antibody/drug complex is then sent to a structure called the lysosome to be broken down.
Nature11mon
β-catenin and its multiple partners: promiscuity explained
β-catenin is a structural component of the cadherin cell adhesion complex, and also functions in the Wnt growth factor signaling pathway.
Morningstar1mon
SOTIO Unveils Promising Preclinical Data on SOT109, a Next-Gen ADC Targeting Cadherin-17 (CDH17) for Colorectal Cancer
SOT109 leverages exatecan-based payload to produce potential best-in-class ADC for validated CDH17 target SOT109 expected to enter a first-in-human Phase 1 clinical trial in 2026 SOTIO Biotech, a ...