Figure 3: Overall structure of the β-catenin-E-cadherin complex. At the atomic level, these interactions include salt bridges, hydrophobic interactions and an extensive network of hydrogen bonds.

One of the major constituents of the cell-adhesion complex in epithelial cells is E-cadherin, a transmembrane protein involved in homotypic cell–cell adhesion. E-cadherin exerts a potent ...

The whole P-cadherin/antibody/drug complex is then sent to a structure called the lysosome to be broken down. "Our results establish an outside-in signaling mechanism that provides fundamental ...