Despite being a mainstay of Parkinson's disease treatment, levodopa, a dopamine-replenishing medication, can cause nasty side ...

py-pde is a Python package for solving partial differential equations (PDEs). The package provides classes for grids on which scalar and tensor fields can be defined. The associated differential ...

An intuitive modeling interface for infinite-dimensional optimization problems.

After hours: March 14 at 4:27:02 PM EDT Loading Chart for CAMP ...

It was reported that there were no significant changes in the level of cardiac cAMP or phosphodiesterase (PDE) that could be responsible for the inotropic effect of amrinone. The original observations ...

Objective: Given the therapeutic and non-therapeutic use of the tadalafil, (phosphodiesterase-5 inhibitor, PDE-5i), we examined its effects on anaerobic performance indices. Methods: In total, 12 well ...

Intracellular signaling encompasses two broad areas, Ca 2+ signaling evoked or modulated by ANs, and signaling by the intracellular second messenger 3’,5’-cyclic adenosine monophosphate (cAMP). Three ...

We demonstrated that phosphodiesterase 1A (PDE1A) promoted metastasis and EMT progression of NSCLC ... PDE1A promotes the metastatic potential in a cAMP-independent manner. (A) NSCLC cells were ...