Human extracellular matrices can be edited in their composition using the CRISPR/Cas9 system, leading to materials exhibiting tailored regenerative capacities.

Subchondral microbiota could enhance cartilage healing and transform components of deep cartilage matrix in metabolites with immunosuppressive properties. The differences of microbiome observed ...

While the common ancestor of vertebrates with synovial joints is still a mystery, the oldest specimen with evidence of these ...

Additionally, therapeutic mechanisms encompass cartilage inflammation, degradation of the cartilage matrix, proliferation and migration of chondrocytes, autophagy, apoptosis, and mitigation of ...

Individual parameters were subsequently altered to assess their effect on the model. Results A progressive loss of cartilage matrix occurred with age. Nitrotyrosine, MMP-13 and activin receptor-like ...

We first address the etiopathophysiology of OA and the mechanisms responsible for breakdown of the cartilage extracellular matrix. We then discuss the potential of MSCs for articular cartilage ...

while knockdown of ADAMTS-7 attenuated degradation of cartilage matrix and protected against OA development, in surgically induced OA models. ADAMTS-7 upregulated TNF-α and metalloproteinases ...

During this process, each group produces its own set of regulator proteins and goes through its own developmental program to produce cartilage and bone. Researchers from the University of Basel ...

Whether it’s an aspiring NFL player, a basketball star, or a weekend warrior, damage to the knee’s articular cartilage can bring everything to a painful halt. Unlike other tissues in the body ...