New research from the Kennedy Institute has revealed how two important proteins, TBK1 and IKKε, play a crucial role in ...

为探究 E3 泛素连接酶自身的翻译后修饰和稳定性，研究人员开展了关于 USP43 与 RNF2 关系的研究。结果发现 USP43 能稳定 RNF2，二者通过调控 TBK1 泛素化和降解影响抗病毒先天免疫，揭示了新的免疫调控机制。 摘要：E3 泛素连接酶通常调节底物蛋白的泛素化和降解 ...

When Wdr5 was disabled, the number of HSPCs dropped significantly, leading to widespread DNA damage and cell death. A key mechanistic insight is that Wdr5 reduces the accumulation of "R-loops ...

Mar. 26, 2025 — Researchers have developed 'tomoseqr' -- a new software tool that enables easy estimation of the three-dimensional (3D) spatial distribution of gene expression. Tomoseqr is free ...

Understanding the differences in the mutations that ... FLIpping the Switch: Boosting Stem Cell Numbers for Therapies Mar. 10, 2025 — A single molecular switch is essential for blood stem cells ...

Advancing single-cell research requires precise and reproducible tissue dissociation techniques. Manual methods can introduce variability, compromise cell viability and hinder downstream applications.